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Hashimotos, of course, is an immune-mediated autoimmune disease of the thyroid gland which already results in damage and inflammation

82 PXR knockout mice were found to be less sensitive to AIH, which implied that PXR mainly played an active role in regulating the cytochrome P450 enzyme system

doi: 10.1016/j.cell.2005.07.002

These two pathways trigger the fibrosis and atrophy of the urethral sphincter muscles with ageing and multiparity

The physiological relevance of the kinetic uncoupling is that it allows the formation of stable complexes, for example, with ironsulfur clusters or disulfide-bonded interaction partners

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